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About Viagra
Sildenafil, known to the public as Viagra, was developed by Pfizer in 1988 to help men who suffer from impotence. Erectile Dysfunction (ED), which is a medical term for impotence, is a sexual dysfunction classified when men have an inability to obtain or maintain an erection. Men who suffer from this condition are still able to ejaculate.
Viagra, an approved ED drug, has been widely used in the UK. It works by increasing blood flow to the penis, helping it to fill with enough blood to cause an erection. Viagra relaxes muscles causing increased inflow of blood and an erection thus enabling sexual intercourse. However, Viagra works only when men are sexually excited.
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How Viagra works?
Viagra is most often used in the treatment of erectile dysfunction. This works by inhibiting a specific enzyme called phosphodiesterase-5 located in the smooth muscle of the arteries that supply blood to the penis.
Nitric oxide (NO) is a chemical produced by special nerve cells. One of the main roles of NO is to trigger the relaxation of the smooth muscle that lines the arteries. This leads to vasodilatation and the lowering of blood pressure. In the penis this causes engorgement as the arteries expand and fill up with blood. The result is an erection that's stimulated by NO.
Nitric oxide acts locally. It diffuses into adjacent cells and binds to an enzyme called guanylyl cyclase. The binding of NO activates the enzyme, stimulating it to produce cyclic guanosine monophosphate or cGMP. During an erection, the cGMP signal leads to changes in phosphorylation of muscle proteins causing the muscles to relax and the arteries to expand.
As you might expect, cGMP is not infinitely stable; otherwise a man might have an erection forever. cGMP is removed by the action of cGMP phosphodiesterase, which converts it to GMP. The turnover of cGMP in the penis is quite rapid leading to lack of signal unless NO is continually produced by the nerve cells in order to replenish the supply of cGMP by reactivating guanylyl cyclase. This production of NO requires the attention of the brain, which has to stay focused on the task at hand.
The smooth muscle cells in the penis contain a special cGMP phosphodiesterase called phosphodiesterase-5 (PDE5). Sometimes the degradation of cGMP by PDE5 outpaces the production of cGMP by guanylyl cyclase. In such cases, the steady-state levels of cGMP aren't sufficient to signal muscle relaxation and no erection occurs. This is a common cause of erectile dysfunction. Viagra works by inhibiting PDE5, thus blocking the breakdown of cGMP. This causes levels of cGMP to increase and an erection is prolonged.
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Sex being one of the most basic physiological needs, Viagra helps you set aside your inhibitions and makes sure that you are able to enjoy your sexual life!
Who can take Viagra?
Viagra has an established safety profile of over 10 years. It has been shown to work safely and effectively in men with erectile dysfunction. This includes:
o Men of all ages o Men who have difficulty all the time or just some of the time o Men with other health issues such as high blood pressure, diabetes, and depression
In order to find out if Viagra is right for you, do speak to your doctor first. He is the best person to tell you if you have ED and can recommend an effective treatment for you. You can also buy Viagra online at online pharmacies on internet.
When to take Viagra?
For best results, Viagra must be taken about one hour before having sex. It starts working in about 10 to 40 minutes after taking a 25mg to 100mg dose, and can work for up to four hours after you take it. Do not take more than one dose per day, as this greatly increases the risk of severely low blood pressure. Viagra works faster when you take it on an empty stomach. It may take longer to work if you take it after eating a high-fat meal.
How to store Viagra?
If you buy Viagra online then you must store it in cool and dry place below 30?? temperature. Viagra should not be stored in heat or dampness, which destroys it.
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